Psoriasis is one of the most confounding diseases in dermatology. It can have severe, crippling manifestations that significantly impact patients’ quality of life—and yet, there are many patients who exhibit only a milder form of the disease for their entire lives. Some patients have serious systemic manifestations, including psoriatic arthritis and cardiovascular disease, but it is not entirely clear why only a subset of patients develop these complications.
Alice Gottlieb, MD, PhD has been at the forefront of psoriasis research and her bench and clinical discoveries have been foundational in describing the interactions of the epidermis and T-cells, thus unveiling the importance of the immune system in active disease. This ushered in biologics for the treatment of psoriasis, which has been transformative. Yet, according to Dr. Gottlieb, there are still significant research and knowledge gaps that need to be addressed to further improve the well-being of many patients.